Greys Anatomyclosed its season 14 premiere with a surprising twist: Amelia Shepherd has a largetumor in her brain.

Could her brain tumor be to blame for some of her impulsive decisions onPrivate Practice?

Was her Runaway Bride moment ahead of the wedding to Owen (Kevin McKidd) a side effect?

CATERINA SCORSONE

Mitch Haaseth/ABC

Who is Amelia, really?

Its a reckoning, if you will, but its also an explanation.

Some of the people who are closest to her, I think its definitely a revelation and also scary.

I cant really speak, so Im trying to find creative ways for other people to discover it.

Thats wherethe comedy thatGreysis striving to return tocomes into play during this rather dark story line.

I dont think I should say anything about that, McKidd says coyly.

I dont want to torture anyone, but thats part of the fun of the show.

But McKidd says Megan (Abigail Spencer) wont be leaving immediately.

Nothing is simple, especially on Greys, McKidd says.

There are some medical developments for Megan that mean that she cant rush off straight away.

Greys Anatomyairs Thursdays at 8 p.m.