Miranda will be reporting in via Zoom.
The YouTube video has over 2 million views and has already helped raise almost $19,000 for Feeding America.
Other late-night hosts have also done YouTube shows from home, with Colbert addressing viewers from hisbathtub on Monday.
Wednesdays charity will be Broadway Cares/Equity Fights AIDS.
Miranda has been doing his part to cheer up fans affected by the pandemic and social distancing measures.
